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| ND Schedule | Week 12 Opponent | Score | Record |
| Texas Longhorns | BYE | BYE | 4-6 |
| Virginia Cavaliers | Duke Blue Devils | W 42-34 | 4-7 |
| Georgia Tech Yellow Jackets | @Miami Hurricanes | L 38-21 | 3-8 |
| Massachusetts Minutemen | Miami Redhawks | L 20-13 | 2-9 |
| Clemson Tigers | Wake Forest Demon Deacons | W 33-13 | 11-0 |
| Navy Midshipmen | @Tulsa Golden Hurricane | W 44-21 | 9-1 |
| Southern Cal Trojans | @Oregon Ducks | L 48-28 | 7-4 |
| Temple Owls | Memphis Tigers | W 31-12 | 9-2 |
| Pittsburgh Panthers | Louisville Cardinals | W 45-34 | 8-3 |
| Wake Forest Demon Deacons | @Clemson Tigers | L 33-13 | 3-8 |
| Boston College Eagles | Notre Dame Fighting Irish (Neutral) | L 19-16 | 3-8 |
| Stanford Cardinal | California Golden Bears | W 35-22 | 9-2 |
Irish Opponent Week 12 Record: 6-5 Irish Opponent Season Record: 72-58
With little to play for having already missed out on a bowl game, Virginia showed up in a big way by knocking off Duke at home Saturday afternoon. Quarterback Matt Johns threw for a career high 344 yards at more than 10 yards per attempt while RB Taquan Mizzell added two scores on the ground. The Hoos defense also forced three turnovers that all led to TDs. The Cavaliers will face Virginia Tech next week where they will try to deny Frank Beamer bowl eligibility in his final regular season game with the Hokies. Georgia Tech continued their tailspin of a season by losing at Miami. Jackets QB Justin Thomas was knocked out of the game early on, leaving backup Matthew Jordan to run the show. Jordan led the Jackets in rushing, but threw for just 59 yards on 8 passes. He was also picked off once. The Jackets secondary allowed Miami QB Brad Kaaya to throw for 300 yards and one TD. GT will close out their season against fellow disappointment UGA next week. Old friend Chuck Martin knocked off UMass after a nice fourth quarter comeback. The road win was the first for the Redhawks in 22 tries. The Minuteman offense didn't make it out of first gear as they were held to just 250 total yards on the afternoon. Blake Frohnapfel completed 50% of his passes for 181 yards, and was picked off once. The Minutemen end their season with a trip to Buffalo next Friday.
Clemson stayed undefeated with an easy win over Wake Forest. The Clemson offense had a big day going for over 550 yards, but they did have four turnovers which limited their scoring output. On defense, the Tigers held Wake to just 152 total yards and had two takeaways of their own. The Tigers end the regular season with a trip to South Carolina, losers Saturday in their SEC-SoCon Challenge game against The Citadel. Navy picked up another big win in the AAC by running over Tulsa. Keenan Reynolds rushed and threw for a TD as the Middies ran for 469 yards. 12 different players for Navy had at least one carry. The Midshipmen travel to Houston with the AAC-West on the line next week, and close the season in early December with the traditional Army-Navy Game. Southern Cal became the second straight Irish opponent to lose to Oregon. Playing with an injured hand, JuJu Smith-Schuster was held to just five catches for 57 yards. Justin Davis had a big day on the ground with 141 yards on only16 carries. The Trojans problems came on defense, however. Royce Freeman racked up 147 yards, and Vernon Adams threw for over 400 yards and six TDs. Southern Cal can still win the South Division of the PAC 12 with a win over UCLA next week. Temple picked up another nice win that should move them back into the top 25. The Owls defense held Memphis to 232 yards while the offense gained 461 themselves. PJ Walker had a nice day at QB throwing for 261 yards and two scores. The Owls can clinch the AAC-East with a win next week over Bob Diaco's UConn Huskies.
Pittsburgh won a high scoring affair with Louisville on the back of a 35 point second quarter. Panthers QB Nathan Peterman threw four of his six TDs in the period, and the defense added a pick six as well. Qadree Ollison had a big day on the ground with 152 yards and a touchdown of his own. The Panthers defense did allow 355 passing yards to the Cards, but stopped them repeatedly on the ground. Louisville rushed for -1 yards on the day. While UNC has already clinched the division, Pitt can move to 9-3 with a win against Miami next week. Next week's opponent added a nice win against Cal on Saturday in The Big Game. Christian McCaffery had what feels like a typical game for him by rushing for just under 200 yards. McCaffery also returned a kickoff for a TD and scored on a 49 yard reception. Kevin Hogan threw for just 96 yards, but the Cardinal attempted just 12 passes in the game. The Stanford defense did allow nearly 400 passing yards to the Bears, but held up better against the run. Cal failed to crack the 100 yard mark as a team. The win clinched the PAC-12 North for the Cardinal, and they will find out their opponent next week.